Composite Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Cell Lymphoma with 17p Deletion: A Case Study 【Abstract】

[N A J Med Sci. 2017;10(1):13-19.   DOI:  10.7156/najms.2017.1001013]

Hanan Armanious, MD, PhD; Jean Deschênes, MD; Wei-Feng Dong, MD, PhD; Iyare Izevbaye, MD, PhD

Here we describe a case of a composite mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small cell lymphocytic lymphoma (CLL/SLL) with 17p deletion in the MCL. The patient presented with 3 years of progressive lymphocytosis. Cervical lymph node biopsy showed morphologic features of nodular MCL and internodular CLL/SLL, two populations of CD5+ cells by flow cytometry, a t(11;14) translocation with a deletion in chromosome 11 by FISH, and biclonal IGH gene rearrangement. In the peripheral blood, flow cytometry showed a single population of CD5+ cells; FISH showed a t(11;14) translocation. Peripheral blood IGH gene rearrangement confirmed a single B cell monoclonal population identical to one of the two lymph node clones.  Peripheral blood karyotyping detected 17p deletion, attributed to the MCL, the sole B cell clonal population in the peripheral blood. The diagnosis was concurrent MCL and CLL/SLL in the lymph node with peripheral MCL harboring a 17p deletion.

Key Words: mantle cell lymphoma; CLL/SLL; Fluorescence in situ hybridization

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Hanan Armanious, MD, PhD;1 Jean Deschênes, MD;2 Wei-Feng Dong, MD, PhD;2 Iyare Izevbaye, MD, PhD3*
1 Department of Laboratory Medicine & Pathology, Molecular Pathology Division, University of Alberta, Edmonton, Alberta, Canada
2 Department of Laboratory Medicine & Pathology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada

*Corresponding Author: Department of Laboratory Medicine & Pathology, Molecular Pathology Division, University of Alberta, 8440 112 Street. Edmonton, Alberta, Canada T6G 2B7. Tel: 780-407-6648,  Fax: 780-407-8599.
(Email: Iyare.Izevbaye@albertahealthservices.ca)

CONFLICT OF INTEREST
The authors have no conflict of interest to disclose.

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